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Spravato®
Treating the Whole Brain—with Spravato at CNS Center
If depression has persisted despite trying multiple medications, you may be a candidate for Spravato® (esketamine) nasal spray. At CNS Center in Chicago, our neurology-led mental health team provides in-office Spravato treatment with careful monitoring and a personalized plan—so you can find relief safely and quickly.
Led by board-certified neurologist Dr. Lenny Cohen and our CNS team, CNS Center delivers comprehensive brain care under one roof, including Deep TMS (BrainsWay®) and Spravato, seven days a week. We accept insurance and work directly with your plan.
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Learn More
What Is Spravato®?
Spravato (esketamine) is an FDA-approved nasal spray for treatment-resistant depression (TRD) in adults and for depressive symptoms with acute suicidal ideation or behavior (in conjunction with an oral antidepressant). Unlike traditional antidepressants that can take weeks, Spravato acts on the glutamate system and may provide relief more rapidly.
At CNS Center, Spravato is administered in-clinic by trained clinicians under a REMS-certified protocol with continuous monitoring—prioritizing your safety, comfort, and outcomes.
Spravato may be appropriate if you’ve experienced:
Ongoing depressive symptoms despite 2 or more adequate trials of antidepressants
Loss of interest, low mood, fatigue, or impaired functioning that persists
Worsening symptoms despite therapy or medication adjustments
Why Choose CNS Center for Spravato in Chicago?
Neurology-Led, Psychiatrist-Directed Care
Our unique model blends neurological insight with psychiatric expertise for deeper evaluation of mood, cognition, sleep, pain, and attention—factors that influence depression and recovery.
Comprehensive Treatment Options
We offer Spravato, BrainsWay Deep TMS (gold standard TMS), medication management, and adjunctive therapies—so your plan is tailored to you.
Convenient, In-Office Care—7 Days a Week
Comfortable treatment suites, easy street parking, and flexible scheduling mean Spravato visits that fit your life.
We Handle Insurance for You
From verification and prior authorization to required documentation, our team manages the process and advocates for coverage.
Faster Access, No Hospital Delays
Get evaluated and scheduled promptly—without long waitlists.
Medical Approach
The Science of Brain Health We take a biological and neurological approach to mental wellness. By utilizing advanced therapies like TMS Therapy, Hyperbaric Oxygen, and nutritional support, we aim to restore neural pathways and improve brain function, going beyond medication alone.
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The BEst Option
Who Is a Good Candidate for Spravato?
You may benefit from Spravato if you:
Are an adult diagnosed with major depressive disorder and haven’t responded to at least two antidepressants
Need faster-acting support while continuing an oral antidepressant
Prefer in-clinic care with medical supervision and structured follow-up
Spravato may not be right for everyone. During your consultation, we review your medical history and discuss considerations such as blood pressure, pregnancy, and other conditions or medications to ensure safety.
What to Expect During Spravato Treatment
Consultation & Care Plan
Meet with our CNS team to confirm eligibility, review medications, and outline goals.
Your First Session (About 2–2.5 Hours in Clinic)
You self-administer Spravato under clinician supervision in a calm, private suite. We monitor your vitals and comfort throughout.
Structured Treatment Schedule
Typical protocol: twice weekly for 4 weeks, then once weekly for 4 weeks, followed by individualized maintenance. You may be able to stop your baseline oral anti-depressant(s).
Recovery & Ride Home
Mild, temporary effects (e.g., dissociation, dizziness, blood pressure changes) can occur. You’ll rest onsite until cleared to leave. You’ll need a ride home and should avoid driving until the next day.
Ongoing Optimization
We track symptoms, adjust dosing as needed, and—when appropriate—combine with Deep TMS or therapy for durable results.
Spravato FAQs
Is Spravato covered by insurance?
Many plans cover Spravato for eligible patients. Our team verifies benefits and completes prior-authorizatinos for you.
How quickly might I feel better?
Some patients report improvement within the first few sessions; results vary. We monitor progress closely and adjust your plan.
Can Spravato be combined with TMS or therapy?
Yes. We often integrate BrainsWay Deep TMS and psychotherapy to enhance and sustain outcomes.
Will I be able to drive after treatment?
No—arrange a ride. Most patients resume normal activities the next day.
Start Spravato in Chicago—On Your Schedule
Don’t let treatment-resistant depression define your life. Get a thorough evaluation and a clear plan—fast, safe, and supported at every step.
Located in Chicago with easy street parking
Appointments available sooner than hospitals
Appointments available sooner than hospitals
We work directly with your insurance